Royal Air Force Typhoon fighter aircraft have conducted a mission with French warplanes in a joint strike against an subterranean weapons facility in Syrian territory used by the IS group, according to the UK's MoD.
The site, identified by reconnaissance, was believed to be storing arms and explosives, the announcement noted, and was situated in hills just above the historic site of Palmyra in Syria's central region.
"Our fighter planes used precision-guided Paveway IV munitions to hit a series of approach shafts down to the depot... preliminary assessments indicate the objective was successfully hit," the MoD said.
There was no evidence of any harm to civilians in the strike conducted Saturday night and every plane involved returned safely, the ministry further stated.
The Typhoon fighters were supported by a Voyager refuelling tanker.
Daesh - also known as ISIS - established militant control over parts of Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates our UK leadership, and determination to stand shoulder to shoulder with our allies, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary the Defence Secretary said.
RAF aircraft have conducted surveillance missions over Syria to "forestall any attempted resurgence" of Islamic State following its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of the UK armed forces participating in this operation for their expertise and their valour," Healey added. "They were part of a great many British personnel deployed over the festive period. This action, to remove terrorist threats who endanger our security, demonstrates how UK forces are always on standby, all year round, keeping Britain secure at home and strong abroad."
In December, the United States armed forces carried out what it described as a "large-scale strike" on Islamic State objectives in Syria, following an assault resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The UN says Daesh still has between 5,000 and 7,000 militants in both countries.